Information Systems is a discipline which connects the concepts, theories, and processes between business world and information technology systems. Teaching information systems subjects present different challenges, as faculty members need to use strategies that can blend the subjects well. Limited research had investigated a number of factors which relate to the selection of instructional or teaching strategies to be used in a face-to-face classroom, outside of the classroom, or in an online learning environment. This study investigated whether gender, rank, age, course level, delivery format, class size, years of prior teaching experience, and availability of teaching assistants are among the factors that relate to the selection of instructional strategies within this discipline. A web-based survey questionnaire was distributed to members of the Association of Information Systems who were teaching in the United States institutions. There were 695 valid responses (24.4% response rate) obtained from 2,835 valid participants. A multiple regression analyses were performed against the top 9 strategies that were frequently used by information systems faculty. The results suggested that not all factors were influential. Depending on which strategies, only six factors had significant influences on the selection of instructional strategies or group of instructional strategies.