Directorate of Academy Operations (DAO) of XYZ University functions to support the ongoing academic process. DAO activities supported by information technology (IT) include: manage student data, manage teaching data, and manage lecturer data. Activities conducted in this research study was to assess the current alignment between IT and business strategy of DAO using the COBIT 4.1. The result shows we can conduct an analysis using the COBIT 4.1 framework to formulate strategic recommendations related to the use of IS/IT by DAO. The purpose of this research is to know the alignment strategic between business strategic of DAO and information technology. Organizations use information technology as a tool to achieve purpose. Often information technology is not participated as strategic tool to achieve organization purpose. Or in other words, organization has different purpose from information technology.